Organic cation transporter expression and function in human pulmonary epithelial cells
نویسندگان
چکیده
منابع مشابه
Effects of Citrus Fruit Juices on Organic Cation Transporter 2 Function and Expression in Vitro
Organic cation transporter 2 (OCT2) plays an important role in the renal clearance of endogenous and exogenous organic cations, including drugs and their metabolites. Citrus fruit juice interactions with the P-gp efflux transporter are well-established, but there is to date no study on the effects of citrus fruit juice on OCT2 function and expression. This paper evaluates the modulating activit...
متن کاملDecreased function of genetic variants, Pro283Leu and Arg287Gly, in human organic cation transporter hOCT1.
We have evaluated the functional consequences of genetic variations in human organic cation transporter hOCT1 (SLC22A1). Three coding single nucleotide polymorphisms (cSNPs) resulted in the amino acid changes Pro283Leu, Arg287Gly and Pro341Leu were assessed. Uptake experiments with transient expression system using HEK293 cells revealed that the variants Pro283Leu and Arg287Gly had completely d...
متن کاملExpression and localization of organic cation/carnitine transporter OCTN2 in Caco-2 cells.
l-Carnitine is derived both from dietary sources and biosynthesis. Dietary carnitine is absorbed in the small intestine and then distributed to other organs. Previous studies using Caco-2 cells demonstrated that the transport of l-carnitine in the intestine involves a carrier-mediated system. The purpose of this study was to determine whether the uptake of l-carnitine in Caco-2 cells is mediate...
متن کاملA nucleoside-sensitive organic cation transporter in opossum kidney cells.
Renal secretion of organic cations and anions are pleiotropic, active processes in mammals. Some nucleosides such as deoxyadenosine (dAdo), 2-chlorodeoxyadenosine, and azidothymidine are secreted by human and rodent kidneys. Previous work (J. A. Nelson, J. F. Kuttesch, Jr., and B. H. Herbert. Biochemical Pharmacology 32: 2323-2327, 1983) indicated a role for the classic organic cation transport...
متن کاملEpithelial calcium transporter expression in human duodenum.
Calcium absorption in intestine and kidney involves transport through the apical membrane, cytoplasm, and basolateral membrane of the epithelial cells. Apical membrane calcium influx channels have recently been described in rabbit (epithelial calcium channel, ECaC) and rat (calcium transport protein, CaT1). We amplified from human duodenum a 446-base partial cDNA probe (ECAC2) having a predicte...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2009
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.23.1_supplement.748.6